5-Amino-1MQ

A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in fat tissue that contributes to obesity and metabolic dysfunction. By blocking NNMT, 5-Amino-1MQ shifts fat cells toward a more metabolically active state, promoting fat loss and improving cellular energy metabolism.

• Inhibits NNMT enzyme to increase intracellular NAD+ and SAM levels
• Promotes shrinkage of adipocytes by activating fat metabolism pathways
• Enhances mitochondrial energy production in muscle and fat tissue

• Liver or kidney disease
• Pregnancy or breastfeeding
• Use of medications metabolized by methyltransferase enzymes

Store at room temperature (15–25°C (59–77°F)) in a cool, dry place. Protect from light and moisture. Keep capsules sealed until use.

Preclinical studies published in Biochemical Pharmacology demonstrated that 5-Amino-1MQ significantly reduced body weight, fat mass, and adipocyte size in diet-induced obesity mouse models without affecting food intake. The compound increased intracellular NAD+ and S-adenosylmethionine (SAM) concentrations. Human clinical trials are pending, but the compound has garnered significant interest in the weight management research community.