AOD-9604

A modified fragment of human growth hormone (amino acids 177-191) with an added tyrosine at the N-terminus. It was developed to isolate the fat-metabolizing activity of GH without its growth-promoting or diabetogenic effects.

• Mimics the lipolytic domain of GH by activating beta-3 adrenergic receptor-mediated fat metabolism
• Inhibits lipogenesis through suppression of key adipogenic transcription factors
• Does not bind the GH receptor or stimulate IGF-1 production

• Active malignancy
• Pregnancy or breastfeeding
• Known hypersensitivity to the compound

Store at 2–8°C (36–46°F) for up to 3 months. Once reconstituted, refrigerate and use within 21 days. Do not freeze after reconstitution.

AOD-9604 underwent Phase II clinical trials for obesity showing modest but statistically significant fat loss compared to placebo. It received GRAS (Generally Recognized as Safe) status from the FDA in 2014 for use as a food substance. Recent research has pivoted toward its potential in cartilage regeneration and osteoarthritis treatment.