ARA-290

An 11-amino acid synthetic peptide derived from the B helix of erythropoietin. Selectively activates the innate repair receptor (IRR) to promote tissue protection and repair without erythropoietic (blood cell) stimulation.

• Activates the innate repair receptor (IRR/EPOR-βcR heterodimer)
• Suppresses pro-inflammatory cytokine release
• Inhibits apoptosis in stressed tissues
• Promotes Schwann cell and neurite migration
• Does not bind the classical erythropoietin receptor

• Known hypersensitivity to erythropoietin-derived peptides
• Pregnancy or breastfeeding
• Active thromboembolic conditions

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 1 week (ideally within 24 hours).

Multiple Phase 2 clinical trials completed for sarcoidosis-associated neuropathy and diabetic neuropathic pain. Demonstrated improved corneal nerve fiber density and reduced neuropathic symptoms. Developed by Araim Pharmaceuticals with promising safety and tolerability data.