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Healing & RecoveryPhase IIIIntermediate

Cerebrolysin

Cerebrolysin (FPF-1070)

Also known as: FPF-1070, Brain Peptide Complex

Overview

A neuropeptide preparation derived from enzymatic breakdown of purified porcine brain proteins. Contains a mixture of small peptides and free amino acids with neurotrophic activity, used clinically for stroke and TBI recovery.

Half-Life
~30 minutes (active metabolites persist longer)
Typical Dose
5–30 mg
Frequency
1x daily for 10-20 day cycles
Cycle Length
10-20 day infusion cycles, repeated as needed

Administration

IntravenousIntramuscular

Benefits

  • Promotes neuronal survival and brain plasticity
  • Accelerates recovery after ischemic stroke
  • Improves cognitive function in TBI patients
  • Neurotrophic factor-like activity (mimics BDNF, NGF)
  • May slow cognitive decline in Alzheimer's disease
  • Enhances synaptic density and dendritic branching

Side Effects

  • Dizziness
  • Headache
  • Injection site pain
  • Nausea
  • Agitation or insomnia (with high doses)
  • Fever (uncommon)

Mechanism of Action

  • Mimics endogenous neurotrophic factors (BDNF, GDNF, NGF-like activity)
  • Promotes neurogenesis and synaptic plasticity
  • Inhibits calpain-mediated neuronal death
  • Reduces amyloid-beta aggregation and tau hyperphosphorylation
  • Modulates GSK-3β and CDK5 kinase pathways

Contraindications

  • Epilepsy or seizure disorders (may lower threshold)
  • Severe renal insufficiency
  • Pregnancy or breastfeeding
  • Known allergy to porcine-derived products

Storage & Reconstitution

Store ampoules at 2–8°C (36–46°F), protected from light. Do not freeze. Use immediately after opening; discard unused portion.

Common peptide amounts:1 mg5 mg10 mg

Research Summary

Approved in over 40 countries for stroke, TBI, and dementia. Multiple Phase 3 RCTs including the CASTA trial (stroke) and large Alzheimer's studies. Cochrane reviews note some positive signals but call for additional high-quality trials. Manufactured by EVER Neuro Pharma (Austria).

Commonly Stacked With

Healing & RecoveryDihexa
CognitiveSemax
CognitiveSelank

This information is for educational purposes only. Always consult a qualified healthcare professional before using any peptide.