GHK-Cu

A naturally occurring copper-binding tripeptide present in human plasma, saliva, and urine. GHK-Cu declines with age and is one of the most studied cosmetic peptides, renowned for stimulating collagen synthesis, improving skin elasticity, reducing fine lines, and promoting hair follicle health. It is a staple ingredient in high-end skincare formulations.

• Delivers bioavailable copper to activate lysyl oxidase for collagen crosslinking
• Upregulates TGF-beta signaling to promote extracellular matrix remodeling
• Increases glycosaminoglycan and decorin production for dermal hydration
• Modulates metalloproteinase activity to balance collagen turnover
• Activates antioxidant genes (SOD, glutathione peroxidase) to combat oxidative skin aging

• Wilson's disease or copper metabolism disorders
• Copper allergy or sensitivity
• Pregnancy or breastfeeding

Store at 2–8°C (36–46°F) for up to 6 months, protected from light. Once reconstituted, refrigerate and use within 30 days. Topical serums: follow manufacturer shelf-life guidelines.

Discovered by Dr. Loren Pickart in the 1970s, GHK-Cu has over 100 published studies. Broad Institute Connectivity Map data showed it modulates expression of ~32% of human genes, reversing many age-related expression patterns. Clinical trials demonstrate increased collagen synthesis, improved skin density, and reduced wrinkle depth. It is the most widely adopted peptide in cosmeceutical formulations worldwide.