GHK-Cu

A naturally occurring copper-binding tripeptide known primarily for skin rejuvenation and wound healing. GHK-Cu is included in the sleep category because gene expression studies reveal it upregulates genes involved in circadian rhythm regulation and nervous system repair. By modulating over 4,000 genes — including those governing neuroinflammation and oxidative stress — GHK-Cu may indirectly support sleep quality through systemic tissue restoration and reduced inflammatory burden.

• Upregulates genes involved in circadian clock maintenance and nervous system repair
• Reduces pro-inflammatory cytokines (IL-6, TNF-alpha) that fragment sleep
• Activates antioxidant pathways (SOD, glutathione) to reduce oxidative sleep disruption
• Promotes stem cell recruitment for overnight tissue regeneration

• Wilson's disease or copper metabolism disorders
• Copper allergy or sensitivity
• Pregnancy or breastfeeding

Store at 2–8°C (36–46°F) for up to 6 months, protected from light. Once reconstituted, refrigerate and use within 30 days. Topical formulations: follow manufacturer guidelines.

Broad Institute Connectivity Map data revealed that GHK-Cu modulates expression of 32% of human genes, including clusters associated with circadian rhythm, neuronal function, and inflammatory regulation. While not traditionally classified as a sleep peptide, its broad gene-regulatory profile supports systemic conditions conducive to restorative sleep. Dr. Loren Pickart's research demonstrated anti-inflammatory and neuroprotective effects that are mechanistically relevant to sleep quality. Clinical evidence for direct sleep improvement is indirect, based on gene expression and anti-inflammatory data rather than sleep-specific trials.