GHRP-6

A hexapeptide growth hormone secretagogue that acts on the ghrelin receptor to stimulate potent GH release. It is notable for also strongly stimulating appetite through ghrelin pathway activation, making it useful where increased caloric intake is desired.

• Agonizes the GHS-R1a (ghrelin) receptor to stimulate GH release from the pituitary
• Activates hypothalamic appetite centers via ghrelin pathway signaling
• Increases gastric motility and gastric acid secretion
• Triggers modest cortisol and prolactin co-release through non-selective receptor activation

• Obesity or conditions where appetite stimulation is undesirable
• Active malignancy
• Uncontrolled diabetes

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 21 days.

GHRP-6 was one of the first synthetic GH secretagogues developed, extensively studied since the 1980s. It has been shown to produce robust, dose-dependent GH release, though with less selectivity than newer GHRPs. Preclinical research has also identified cardioprotective properties, with studies showing reduced infarct size in animal models of myocardial ischemia.