Hexarelin

A potent synthetic hexapeptide GH secretagogue and one of the strongest GHRPs available. It produces substantial GH release but is limited by rapid desensitization with continued use and notable effects on cortisol and prolactin.

• Strong agonism of the GHS-R1a receptor producing maximal GH secretory response
• Activates cardiac GHS receptors, contributing to cardioprotective effects independent of GH
• Non-selective receptor activation leads to co-release of cortisol, prolactin, and ACTH

• Active malignancy
• Conditions worsened by cortisol elevation (e.g., Cushing's)
• Pregnancy or breastfeeding
• History of pituitary tumors

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 14 days.

Hexarelin has been studied in clinical trials for GH deficiency and cardiac recovery. It produces the most potent acute GH response among GHRPs but shows significant tachyphylaxis (desensitization) within 1-2 weeks of continuous use. Research on its cardioprotective effects is particularly noteworthy, with studies showing improved cardiac function in heart failure models independent of GH release.