KPV

A tripeptide fragment from the C-terminus of alpha-melanocyte stimulating hormone (alpha-MSH). Possesses potent anti-inflammatory and antimicrobial properties without melanogenic effects. Particularly relevant for immune regulation in gut and mucosal tissues.

• Inhibits NF-kB nuclear translocation and transcriptional activity
• Reduces pro-inflammatory cytokine secretion (TNF-alpha, IL-6, IL-1-beta)
• Enters colonic epithelial cells to directly suppress inflammasome activation
• Modulates MAPK signaling pathways in immune cells
• Exhibits direct membrane-disrupting antimicrobial activity

• Pregnancy or breastfeeding
• Active immunosuppressive therapy
• Autoimmune conditions (consult physician)

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 2 weeks. Oral capsules: store in a cool, dry place.

Studied in preclinical models of inflammatory bowel disease, colitis, and skin inflammation. Demonstrated efficacy comparable to standard anti-inflammatory treatments in murine IBD models. Strong in vitro evidence for NF-kB inhibition. Cross-reference: see kpv in healing-recovery for tissue repair context.