AHK-Cu

A copper-binding tripeptide structurally related to GHK-Cu but with distinct receptor binding properties. AHK-Cu has been shown to be a particularly potent stimulator of hair follicle growth, outperforming both GHK-Cu and minoxidil in certain in vitro models. It also promotes collagen synthesis and wound healing, though its primary cosmetic interest lies in hair restoration.

• Binds copper(II) ions and delivers them to dermal papilla cells
• Upregulates VEGF expression to enhance follicular blood supply
• Activates Wnt/beta-catenin signaling pathway in hair follicle stem cells
• Stimulates extracellular matrix production in the dermal papilla

• Wilson's disease or copper metabolism disorders
• Copper allergy
• Pregnancy or breastfeeding

Store at 2–8°C (36–46°F) for up to 3 months. Once reconstituted, refrigerate and use within 21 days. Topical formulations: stable at room temperature per manufacturer guidelines.

Research published in the Journal of Biological Chemistry and related journals demonstrated that AHK-Cu stimulates dermal papilla cell proliferation more effectively than GHK-Cu at equivalent concentrations. A 2007 study showed that AHK-Cu increased hair follicle size and prolonged the anagen (growth) phase in organ culture models. While clinical trial data in humans remains limited, its mechanism of action through copper delivery and Wnt pathway activation makes it a promising candidate for alopecia treatment.